Forschung

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Forschungsinteressen
Forschung Intensivmedizin
  • Frührehabilitation/mobilisation
  • Langzeitoutcome von Intensivpatienten
  • Ernährung des Intensivpatienten
  • Frailty

Forschung Notfallmedizin
  • Schmerztherapie
  • Beatmung

Forschung Anästhesie



Bibliography und Kollaborationen

Originalarbeiten

Erst- oder Letztautor

-     Schaller SJ, Fink H, Ulm K, Blobner M. Sugammadex and neostigmine dose-finding study for reversal of shallow residual neuromuscular block. Anesthesiology. 2010;113(5):1054-60.

-       Kaufhold N*, Schaller SJ*, Stauble CG, et al. Sugammadex and neostigmine dose-finding study for reversal of residual neuromuscular block at a train-of-four ratio of 0.2 (SUNDRO20). Br J Anaesth. 2016;116(2):233-40. * shared first authorship

-     Schaller SJ, Anstey M, Blobner M, et al. Early, goal-directed mobilisation in the surgical intensive care unit: a randomised controlled trial. Lancet. 2016;388(10052):1377-88.

-     Schaller SJ, Stauble CG, Suemasa M, et al. The German Validation Study of the Surgical Intensive Care Unit Optimal Mobility Score. J Crit Care. 2016;32:201-6.

-     Schaller SJ, Alam SM, Mao J, et al. Pharmacokinetics cannot explain the increased effective dose requirement for morphine and midazolam in rats during their extended administration alone or in combination. J Pharm Pharmacol. 2017;69(1):82-8.

-     Schaller SJ, Nagashima M, Schonfelder M, et al. GTS-21 attenuates loss of body mass, muscle mass, and function in rats having systemic inflammation with and without disuse atrophy. Pflugers Arch 2018;470:1647-57.

-     Schaller SJ, Kappler FP, Hofberger C, et al. Differences in pain treatment between surgeons and anaesthesiologists in a physician staffed prehospital emergency medical service: a retrospective cohort analysis. BMC anesthesiology 2019;19:18.

-     Schaller SJ, Scheffenbichler FT, Bose S, et al. Influence of the initial level of consciousness on early, goal-directed mobilization: a post hoc analysis. Intensive care medicine 2019;45:201-10.

-     Schaller SJ, Altmann S, Unsworth A, et al. Continuous chest compressions with a simultaneous triggered ventilator in the Munich Emergency Medical Services: a case series. Ger Med Sci 2019;17:Doc06.

-     Nydahl P, Spindelmann E, Hermes C, Kaltwasser A, Schaller SJ. German Network for Early Mobilization: Impact for participants. Heart Lung. 2020;49(3):301-3.

-     Hermes C, Nydahl P, Blobner M, Dubb R, Filipovic S, Kaltwasser A, Ulm B, Schaller SJ. Assessment of mobilization capacity in 10 different ICU scenarios by different professions. PLoS One 2020; 15(10): e0239853

-     Fuest K, Lorenz M, Dorfhuber F, von Dincklage F, Mörgeli R, Kuhn KF, Jungwirth B, Kanz KG, Blobner M, Schaller SJ. Comparison of volume-controlled, pressure-controlled, and chest compression-induced ventilation during cardiopulmonary resuscitation with an automated mechanical chest compression device: A randomized clinical pilot study. Resuscitation. 2021;166:85-92.

-     Kuhn KF, Grunow JJ, Leimer P, Lorenz M, Berger D, Schefold JC, Weber-Carstens S, Schaller SJ. Assessment of magnetic flux density properties of electromagnetic noninvasive phrenic nerve stimulations for environmental safety in an ICU environment. Sci Rep. 2021;11(1):16317.

Koautorenschaften

-     Kramer C, Jordan D, Kretschmer A, Lehmeyer V, Kellermann K, Schaller SJ, Blobner M, Kochs EF, Fink H. Electromyographic permutation entropy quantifies diaphragmatic denervation and reinnervation. PLoS One. 2014;9(12):e115754.

-     Baumuller E, Schaller SJ, Chiquito Lama Y, Frick CG, Bauhofer T, Eikermann M, Fink H, Blobner M. Postoperative impairment of motor function at train-of-four ratio >/=0.9 cannot be improved by sugammadex (1 mg kg-1). Br J Anaesth. 2015;114(5):785-93.

-     Blobner M, Frick CG, Stauble RB, Feussner H, Schaller SJ, Unterbuchner C, Lingg C, Geisler M, Fink H. Neuromuscular blockade improves surgical conditions (NISCO). Surg Endosc. 2015;29(3):627-36.

-     Nagashima M, Sasakawa T, Schaller SJ, Martyn JA. Block of postjunctional muscle-type acetylcholine receptors in vivo causes train-of-four fade in mice. Br J Anaesth. 2015;115(1):122-7.

-     Stauble CG, Stauble RB, Schaller SJ, Unterbuchner C, Fink H, Blobner M. Effects of single-shot and steady-state propofol anaesthesia on rocuronium dose-response relationship: a randomised trial. Acta Anaesthesiol Scand. 2015;59(7):902-11.

-     Muessig JM, Nia AM, Masyuk M, Lauten A, Sacher AL, Brenner T, Franz M, Bloos F, Ebelt H, Schaller SJ, Fuest K, Rabe C, Dieck T, Steiner S, Graf T, Janosi RA, Meybohm P, Simon P, Utzolino S, Rahmel T, Barth E, Schuster M, Kelm M, Jung C. Clinical Frailty Scale (CFS) reliably stratifies octogenarians in German ICUs: a multicentre prospective cohort study. BMC Geriatr. 2018;18(1):162.

-     Greco M, Schaller SJ, Galarza L, Weiss B, ESICM NCot. New scoring criteria for ESICM NEXT fellowship evaluation: toward improved fairness. Intensive care medicine. 2020;46(5):1052-3.

-     Bruno RR, Wernly B, Beil M, Muessig JM, Rahmel T, Graf T, Meybohm P, Schaller SJ, Allgauer S et al. Therapy limitation in octogenarians in German intensive care units is associated with a longer length of stay and increased 30 days mortality: A prospective multicenter study. Journal of critical care. 2020;60:58-63.

-     Azoulay E, De Waele J, Ferrer R, Staudinger T, Borkowska M, Povoa P, Iliopoulou K, Artigas A, Schaller SJ, Shankar-Hari M, et al. International variation in the management of severe COVID-19 patients. Crit Care. 2020;24(1):486.

-     Azoulay E, De Waele J, Ferrer R, Staudinger T, Borkowska M, Povoa P, Iliopoulou K, Artigas A, Schaller SJ, Shankar-Hari M, et al. Symptoms of burnout in intensive care unit specialists facing the COVID-19 outbreak. Ann Intensive Care. 2020;10(1):110.

-     Berger MM, Appelberg O, Reintam-Blaser A, Ichai C, Joannes-Boyau O, Casaer M, Schaller SJ, Gunst J, Starkopf J; ESICM-MEN section. Prevalence of hypophosphatemia in the ICU - Results of an international one-day point prevalence survey. Clin Nutr 2021; 40(5): 3615-21.

-     Scheffenbichler FT, Teja B, Wongtangman K, Mazwi N, Waak K, Schaller SJ, Xu X, Barbieri S, Fagoni N, Cassavaugh J, Blobner M, Hodgson CL, Latronico N, Eikermann M. Effects of the Level and Duration of Mobilization Therapy in the Surgical ICU on the Loss of the Ability to Live Independently: An International Prospective Cohort Study. Critical care medicine 2021; 49(3): e247-e57.

-     Lichtner G, Balzer F, Haufe S, Giesa N, Schiefenhövel F, Schmieding M, Jurth C, Kopp W, Akalin A, Schaller SJ, Weber-Carstens S, Spies C, von Dincklage F. Predicting lethal courses in critically ill COVID-19 patients using a machine learning model trained on patients with non-COVID-19 viral pneumonia. Sci Rep 2021; 11(1): 13205.

 

Originalarbeiten als Kollaborateur oder Mitglied der Study Group

-     Flaatten H, …, VIP study group. The impact of frailty on ICU and 30-day mortality and the level of care in very elderly patients (>/= 80 years). Intensive Care Med. 2017;43(12):1820-8.

-     Guidet B, …, VIP study group. Withholding or withdrawing of life-sustaining therapy in older adults (>/= 80 years) admitted to the intensive care unit. Intensive Care Med. 2018;44(7):1027-38.

-     Kirmeier E, …, Blobner M; POPULAR Contributor. Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study. The Lancet Respiratory Medicine 2019;7:129-40.

-     Guidet B, …, Flaatten H and VIP2 group. The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study. Intensive care medicine. 2020;46(1):57-69.

-     Ibarz, M., …, A. Artigas, and VIP study group. Sepsis at ICU admission does not decrease 30-day survival in very old patients: a post-hoc analysis of the VIP1 multinational cohort study. Ann Intensive Care. 2020;10:56.

-     De Bus L, …, De Waele JJ and Diana study group. Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study. Intensive care medicine. 2020;46(7):1404-17.

-     Santer, P., …, M. Eikermann, and Midas Study Group. Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial. Intensive care medicine 2020;46:1884-93.

-     Gupta A, …, Schyns-van den Berg AMJV; EPiMAP collaborators. Management practices for postdural puncture headache in obstetrics: a prospective, international, cohort study. British journal of anaesthesia 2020; 125(6): 1045-55.

-     Scheffenbichler L, …, Eikermann M; SOMT Team. Influence of the acuity of patients' illness on effectiveness of early, goal-directed mobilization in the intensive care unit: a post hoc analysis. Crit Care 2020; 24(1): 663.

-     Labeau SO, …, Blot SI; DecubICUs Study Team; European Society of Intensive Care Medicine (ESICM) Trials Group Collaborators. Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study. Intensive care medicine 2021; 47(2): 160-9.

-     Haas LEM, …, de Lange DW; VIP2 study group. Frailty is associated with long-term outcome in patients with sepsis who are over 80 years old: results from an observational study in 241 European ICUs. Age Ageing 2021.

-     Jung C, …, Guidet B; COVIP study group. The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study. Crit Care 2021; 25(1): 149.

-     Wernly B, …, Jung C; VIP2 study group. Provision of critical care for the elderly in Europe: a retrospective comparison of national healthcare frameworks in intensive care units. BMJ open 2021; 11(6): e046909.

-     Robba C, …, Citerio G; SYNAPSE-ICU Investigators. Intracranial pressure monitoring in patients with acute brain injury in the intensive care unit (SYNAPSE-ICU): an international, prospective observational cohort study. Lancet Neurol 2021; 20(7): 548-58.

-     Fronczek J, …, Szczeklik W; VIP1; VIP2 study group. Relationship between the Clinical Frailty Scale and short-term mortality in patients >/= 80 years old acutely admitted to the ICU: a prospective cohort study. Crit Care 2021; 25(1): 231.

 

Übersichtsarbeiten

-     Schaller SJ, Fink H. Sugammadex as a reversal agent for neuromuscular block: an evidence-based review. Core evidence. 2013;8:57-67.

-     Schaller SJ, Lewald H. Clinical pharmacology and efficacy of sugammadex in the reversal of neuromuscular blockade. Expert Opin Drug Metab Toxicol. 2016;12(9):1097-108.

-     Fuest K, Schaller SJ. Recent evidence on early mobilization in critical-Ill patients. Curr Opin Anaesthesiol. 2018;31(2):144-50.

-     Fuest K, Schaller SJ. [Early mobilisation on the intensive care unit : What we know]. Med Klin Intensivmed Notfmed. 2019;114(8):759-64.

-     Nydahl P, Hermes C, Spindelmann E, Kaltwasser A, Schaller SJ. [The Early Mobilization Network]. Med Klin Intensivmed Notfmed. 2020.

-     Reintam Blaser A, Gunst J, Ichai C, Casaer MP, Benstoem C, Besch G, Dauger S, Fruhwald SM, Hiesmayr M, Joannes-Boyau O, Malbrain MLNG, Perez MH, Schaller SJ, de Man A, Starkopf J, et al. Hypophosphatemia in critically ill adults and children - A systematic review. Clin Nutr 2021; 40(4): 1744-54.

 

Sonstige Publikationen

-     Eikermann M, Schaller SJ, Kasotakis G, Anstey M, Houle T. Early goal-directed mobilisation after surgery - Authors' reply. Lancet. 2017;389(10070):695-6.

-     Schaller SJ, Nydahl P, Blobner M, Latronico N, Hodgson C. What does the EPICC trial really tell us? 2018. Available from: https://thorax.bmj.com/content/73/3/213.responses#what-does-the-epicc-trial-really-tell-us.

-     Schaller SJ. Das Ziel: Der gehende Intensivpatient. Intensiv-News. 2017(01/2017):13-5.

-     Dorfhuber F, Schaller SJ. Möglicher Einfluss von mechanischen Thoraxkompressionssystemen und supraglottischen Atemwegshilfen auf das Outcome nach einem Kreislaufstillstand. Notfall + Rettungsmedizin. 2018;21(8):697-700.

-     Weiss B*. Statement paper on diversity for the European Society of Intensive Care Medicine (ESICM). Intensive care medicine 2019;45:1002-5.

* Schaller SJ was part of the Diversity Task Force Working Group

-     Kuhn KF, Schaller SJ. Comment on Early versus delayed mobilization for in-hospital mortality and health-related quality of life among critically ill patients: a systematic review and meta-analysis (Okada et al., Journal of Intensive Care 2019). Journal of intensive care. 2020;8:21.

-     Hill A, Heyland DK, Elke G, Schaller SJ, Stocker R, Haberthur C, et al. Meeting nutritional targets of critically ill patients by combined enteral and parenteral nutrition: review and rationale for the EFFORTcombo trial. Nutr Res Rev. 2020:1-9.

-     Schaller SJ, Fuest K, Ulm B, Schmid S, Bubb C, von Eisenhart-Rothe R, et al. Substitution of perioperative albumin deficiency disorders (SuperAdd) in adults undergoing vascular, abdominal, trauma, or orthopedic surgery: protocol for a randomized controlled trial. Trials. 2020;21(1):726.

-     Edel A, Reinhart K, Schaller SJ. [Critical statement on selected recommendations of the new German S3 Sepsis Guideline]. Med Klin Intensivmed Notfmed 2020;115:505-7.

-     Hermes C, Adrigan E, Dubb R, Kaltwasser A, Kuhn KF, Nessizius S, Nydahl P, Steinböck M, Schaller SJ. Reflektiert und mit Augenmaß einsetzen (Robotik zur Unterstützung der Frühmobilisierung). PflegeIntensiv 2020; (4): 14-21.

-     Schaller SJ, Paul N, Grunow JJ, Weiss B, Spies CD. The Post-ICU Patient. ICU Management & Practice 2020; (4): 275-82.
- Hodgson CL, Schaller SJ, Nydahl P, Timenetsky KT, Needham DM. Ten strategies to optimize early mobilization and rehabilitation in intensive care. Crit Care (2021) 25:324

 

Buchbeiträge

-     Schaller SJ. Kapitel 11 - Mobilisation. In: Weigand MA, Hecker A, Mayer K, Michalski D, eds. Intensivmedizin compact: Thieme; 2021.

-     Lang JK, Schaller SJ, Hodgson CL. Implementing Early Mobilisation in the Intensive Care Unit. In: Haines K, McPeake J, Sevin CM, eds. Improving Critical Care Survivorship: Springer International Publishing; 2021.